A.Prof. Zhenbo Xu | 徐振波副教授
South China University of Technology, China
华南理工大学
Dr. Dingqiang Chen | 陈定强博士
Zhujiang Hospital of Southern Medical University, China
南方医科大学珠江医院
Prof. Ningsun Yang | 楊寧蓀教授
Academia Sinica, Taipei
国立中央研究院
Title: Developing Anti-Cancer Metastasis Phytomedicines via R&D into Multi-faceted Immune Cell and Signaling Activities
Abstract: Recent advent in developing medical biotechnology for anti-cancer metastasis has resulted into two main strategies, namely the immune check point inhibitors and the activation of tumor cell lysate -mediated immune cell systems (e.g. dendritic cells). On the other hand, it is very rewarding to observe that a number of phytochemicals derived from traditional medicines have been recognized for potential future clinical application, as evidenced by the recent award of Nobel price in Physiology and Medicine to Prof. Youyou Tu of China, and to two other scientists.
With the above observations, my laboratory has performed a series of experimental studies ( see attached References as follows), aiming at employing the above three aspects into consideration, for potential future immuno-therapeutics against cancers. It is important to note here that all of the four phytochemicals to be discussed below were studied by using a “single compound” phytochemical, instead of using complex compound mixtures from test medicinal herbal extracts.
Prof. Khalilah ABD Khalil
Universiti Teknologi MARA Shah Alam, Selangor, Malaysia
Title: Sustainability of Probiotic for Health Benefits
Abstract: The commercial interest of probiotic application is increasing due to their functionality in boosting health benfits to consumer. These bacteria were discovered to pose benefits to the healthy of our gut which extend our overall health. Research on probiotic is flourishing amd there is still a lot to be understood. In order to ensure probiotic able to booth it’s health benefits, the viability of the cells is the first priority. Skim milk and aloe vera media were used to cultivate probiotic to obtain optimum dosage ( >106 cfu/mL). High cell densities of probiotic was further encapsulate with several encapsulating matrices in order to protect the cells from acid environment after exposed to gastric fluid. Under intestinal condition, the cells begin to release from encapsulating matrices and attached to the intestinal lining of the cell wall. In this study, CaCo2 cells was used to represent colon cancer cell. CaCo2 cells death can be observed after the attchment of released probiotic. However, CaCo2 cells death mechanism need to be understood and explored. Therefore, fundamental research on autophagy effect of probiotic on CaCO2 cells and understanding of the characteristics of the probiotic are still requirred.
